It is in the South of Serbia. It consists of 7 Municipalities:

1. Vladicin Han Municipality, town Vladicin Han
2. Surdulica Municipality, town Surdulica
3. Bosilegrad Municipality, town Bosilegrad
4. Trgoviste Municipality, town Trgoviste
5. Vranje Municipality, town Vranje
6. Bujanovac Municipality, town Bujanovac
7. Presevo Municipality, town Presevo

Pcinja Region has population of 243.529 people. The main town in this Region is Vranje.

Cultural and Historical sights date from many centuries ago. The oldest military fortress is from XIII Century and it is called Markovo kale. There are also some well known places such as Turkish bath-hamam from XVI century, Pasha’s Palace from 1765. where the gymnasium was founded in 1881.

Vranjska Spa is an extraordinary place in this region-thermo-mineral water which heals lot of diseases.

Economy in Vranje consists of industry, mining, construction, trade, agriculture and forestry.

Tobacco industry, textile industry and furniture industry are the most well known industries in this region. Vranje Municipality is the biggest Municipality and it has the greatest number of population in the whole region, and it is the seat of that region. Five Municipalities from seven of them has a cross-border characteristic. Bosilegrad is cross-border area to Bulgaria, with its boundary of 54km, Surdulica Municipality with its boundary of 68km, Presevo Municipality with its boundary of 60km, Bujanovac Municipality with its boundary of 14km. The whole area is hilly-mountain.